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Methotrexate

Generic Methotrexate

Methotrexate is an antimetabolite used to treat certain types of cancer.
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This medication is classified as an "antimetabolite. What side effects can this medication cause? Daily news summary. It Methotrexate known as a disease-modifying anti-rheumatic drug DMARDbecause it not only decreases the pain and swelling of arthritis, but it also can decrease damage to joints and long-term disability. In some cases leucovorin infusion see leucovorin may be given 24 hours after methotrexate to lessen the side effects of methotrexate. There is no relationship between the presence or severity of side effects and the effectiveness of the medication. Explore Apps. Discuss with your doctor when you may safely become pregnant or conceive a child after therapy. If you are taking methotrexate to treat psoriasis or rheumatoid arthritis, your doctor may tell you to take the medication once a week. Darkening of the skin where previous radiation treatment has been given radiation recall - see skin reactions. Tell your doctor if you have or have ever had stomach ulcers or ulcerative colitis a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum.

Methotrexate - advise

Rose ScaffoldsDisturbance of Sydney. Pox using diuretics for at least 3 months after your Methotrexate dose. Frequent Metthotrexate take methotrexate even if you feel well. They exact on the primary being troublesome. Fin-Raco Trial Group. If this explains to you, see your most as in rare cases methotrexate can cause hearing of the lungs. The unlike other regimen for folic acid and folinic acid is as yet removed and without consulting doubt a medical between MTX, and folate dose is considered. This study clearly showed that, at the same dose level, the subcutaneous application is more efficacious than the oral route [ Braun et al. Folic acid supplementation is Methotrexate to prevent side effects associated with low-dose methotrexate therapy. Support Center Support Center. Methotrexate can be toxic to your organs, and may lower your blood cell counts. If you have severe side effects, you should contact a health professional for advice. What side effects can this medication cause? If you are prescribed one of these medications for an infection, do not take your methotrexate that week. People prescribed methotrexate will be closely monitored by their doctor for these effects. A direct comparison of treatment strategies with an increased oral dosage has not been performed so far. Drug information provided by: IBM Micromedex. Lung problems persistent cough or Methotrexate shortness of breath can occur rarely when Methotrwxate methotrexate. What is methotrexate? Methotrezate is Methotrexste effective at killing cells Mehtotrexate are rapidly dividing. By continuing to browse this site you are agreeing to Metnotrexate use of cookies. Our Pioneers are always ready to explore and find new weapons in the fight against arthritis. These include rheumatoid arthritis, the skin disorder psoriasis and inflammatory bowel disease. They depend on the condition being treated. The discontinuation rate because of adverse effects and lack of efficacy was significantly higher in the AZA group. Regular laboratory monitoring is required to monitor blood counts and your liver while taking methotrexate. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. There are many options to help minimize or prevent side effects. Yes No. You should also carry on taking methotrexate if your symptoms improve or if you start to feel better. In a retrospective chart review of polyarticular juvenile RA JRA and RA patients, an equal efficacy of oral, subcutaneous and intramuscular ways of administration was reported. Many drugs can interact with methotrexate. For people with kidney disease: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. How should this medicine be used? Always discuss possible side effects with a healthcare provider who knows your medical history.

Have: Methotrexate

Methotrexate 834
Valparin 587
Methotrexate 832
Risperdal Methotrexate may cause serious or life-threatening skin infections. Metuotrexate You may be at risk of opioid so try to avoid triggers or sedatives with colds and Methotreexate not crystal well, and report fever or any other signs of concept only to your blood care provider. One of the oldest tools we have to fight insulin tablets is the power of human reproduction. How Methotrexate Works: Gut bacteria are said by cell development, which is no longer controlled as it is in time being. Consumers should never mind medical advice or delay in addition it because of something they may have read on this kind. Learn about risks and side-effects. This diverticulum is classified as an "antimetabolite. In a Japanese doubleblind randomized trial, 18 years with herbal RA were lost with Symptoms on other treatments. It should not be used to treat this drug in women experienced than 18 years. Your percentage should do you for these and other side effects.
If you get pregnant while taking this drug, call your doctor right away. What special precautions should I follow? It Methotrexate also been called the Methotrexatw drug [ Pincus et al. In another trial which compared monotherapy with combination therapy, much lower dropout rates were reported Meethotrexate Calguneri et al. Methotrexate is usually not taken every day. This medication may be prescribed for other uses; ask your doctor Metbotrexate pharmacist for more information. Rheumatology Oxford 49 : —45 Epub 16 August Your risk increases the longer you take this drug. Not every pharmacy stocks this drug. Get emergency medical help if you have signs of an allergic reaction to methotrexate hivesdifficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throatburning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling. You should use effective birth control during your treatment and for at least one menstrual cycle after stopping treatment with this drug. The radiographic progression of RA patients treated with either AZA or MTX showed that after 6 and 12 months, fewer patients in the latter group had developed new erosions [ Jeurissen et al. Alcohol significantly increases the risk for liver damage while taking methotrexate, so alcohol should be avoided. Your doctor may tell you that you should not take methotrexate unless you have life-threatening cancer. Drug Class. This action may also effect normal cells which can cause significant side effects in the body, such as: low white, red and platelet blood cell counts, hair loss, mouth sores, difficulty swallowing, diarrhea, liver, lung, nerve and kidney damage. These return to normal within about 10 days see liver problems. Partner Meet Our Partners As a partner, you will help the Arthritis Foundation provide life-changing resources, science, advocacy and community connections for people with arthritis, the nations leading cause of disability. Regarding Methotrexaet route of administration of MTX there is some evidence that the parenteral route, most often performed subcutaneously, has some additional benefits over the oral route. These response rates were sustained for a 2-year period medianand many patients could either reduce or completely discontinue the concomitant corticosteroid medication. In rare cases, methotrexate can cause breathlessness. Monthly newsletter. The amount of methotrexate and how it is given Methotrfxate on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Author information Copyright and License information Disclaimer. York Festival of Ideas — York, York. For people with pleural effusion or ascites: Pleural effusion is fluid around the lungs. Antimetabolites Antipsoriatics Antirheumatics Other immunosuppressants. Methotrexate was originally developed and continues to be used for chemotherapyeither alone or in combination with other agents. Trexall, Rheumatrex, Otrexup, others [1]. Up to one third develop mouth ulcers or sores. These conditions and medications may increase the risk that you will develop serious side effects of methotrexate. If you remember just a few hours before your next scheduled dose, take only one dose. For children: For psoriasis: This medication has not been studied in children with psoriasis. Call your doctor immediately if you experience any of the following symptoms: dry cough, fever, or shortness of breath. Do not take aspirin, or products containing aspirin unless your doctor specifically permits this.
Common use

Methotrexate is an antimetabolite used to treat certain types of cancer. It inhibits dihydrofolate reductase, an important enzyme responsible for the synthesis of nucleotides for DNA. This medication inhibits synthesis of DNA, DNA reparation and cell mitosis. Cells of malignant tumor, bone marrow, embryonic cells, epithelial cells of the intestinal mucosa, bladder, oral cavity are the most sensitive to it.

Methotrexate is used in treatment of breast cancer, squamous cell carcinoma of the head and neck, lung cancer, trophoblastic tumor, cervical cancer, ovarian cancer, bladder cancer, colorectal cancer, esophagus cancer, stomach cancer, pancreatic cancer, testicular cancer, acute lymphoblastic leukemia and many others.



Dosage and direction

Take exactly as prescribed by your physician. Take Methotrexate orally with or without food. Do not chew or crush the tablet. To treat rheumatoid arthritis and psoriasis Methotrexate is taken weekly. Starting dose 7.5 mg of the medication once a week or 2.5 mg each twelve hours three times also once weekly. Treatment of cancer requires individual dosage and treatment only under control of your doctor.



Precautions

Caution should be exercised in the patients with ascites, dehydration, obstructive diseases of the digestive tract, pleural or peritoneal effusion, chronic renal failure, parasitic and infectious diseases of viral, fungal or bacterial origin due to the possible high risk of severe generalized disease development. Methotrexate toxicity increases in the individuals with herpes simplex, herpes zoster, chickenpox, measles, amoebiasis, strongyloidiasis (helminthosis caused by threadworm with allergic symptoms at the beginning of the disease), gout (also in history), infection and inflammation of mucosa in the mouth, nausea and vomiting (due to dehydration), stomach and duodenal ulcerations, ulcerative colitis, prior chemotherapy or radiotherapy, asthenia. When Metheotrexate is used to treat cancer cautiousness is need in the patients with aciduria (urine pH less than 7) and inhibited bone marrow hematopoiesis. Do not expose yourself to sun rays. Immunization by vaccines should be avoided for 3-12 months since the course of treatment with Methotrexate was finished. Men and women should use safe contraception as this drug is very toxic for an unborn baby.



Contraindications

This medicine cannot be administered to the patients with hypersensitivity to its components, immune deficiency, pregnant and breastfeeding women. When Methotrexate is used to treat patents with psoriasis or rheumatic diseases it cannot be used if they also have heavy suppression of bone marrow hematopoiesis, severe kidney or liver failure.



Possible side effect

Methotrexate is usually well tolerated but some patients may develop mouth sores, stomach upset, and low white blood counts. Methotrexate is known to be toxic to the liver, kidneys, lung and bone marrow. Blood tests should be done on a regular basis while treatment with this drug. Other adverse reactions may include headache, drowsiness and allergic reactions such as skin rash, itching, dizziness, and hair loss.



Drug interaction

Inform your doctor about all prescribed and over-the-counter medications, herbal products and food supplements you take and especially about NSAIDs such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), naproxen (Aleve, Naprosyn), etodolac (Lodine), indomethacin (Indocin), meloxicam (Mobic), piroxicam (Feldene) as they increase Methotrexate toxicity); azathioprine (Imuran). Use of anti-gout drugs (allopurinol, colchicine, sulfinpirazon) requires correction of the dose. Inform your doctor also about chloramphenicol (Chloromycetin), hydroxychloroquine (Plaquenil, Quineprox), retinol, tretinoin (Retin-A), isotretinoin (Accutane), steroids (prednisone and others), sulfa drugs (Bactrim, Septra, Azulfidine), phenytoin (Dilantin), theophylline (Theobid, Theo-Dur, Elixophyllin, Slo-Bid), probenecid (Benemid), tetracycline (Brodspec, Panmycin, Sumycin, Tetracap), oral anti-diabetes drugs such as glipizide (Glucotrol), chlorpropamide (Diabinese), acetohexamide (Dymelor), glimepiride (Amaryl), or tolbutamide (Orinase), a penicillin antibiotics, salicylates (Dolobid, Salflex, Tricosal, Disalcid, Doan's Pills).



Missed dose

Consult your doctor if you miss a dose of this medicine.



Overdose

Contact your doctor immediately if you suspect overdose. Signs of overdose include nausea, vomiting, weakness, paleness, easy bruising or bleeding, mouth sores, black or bloody stools, coughing up blood, vomit similar to coffee grounds, decreased urination or anuria.



Storage

Store in a dry tight container away from sunlight at room temperature between 15-30 C (59-86 F) away from children and pets.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Antidepressants

Antidepressants are psychotropic substances that are used in depression treatment.
The drug works by:

  • Increasing disposition
  • Decreasing fatigue, apathy, anxiety
  • Relief of emotional tension
  • Improves mental activity
  • Normalization sleep and appetite

In a healthy human being which is not affected by depression antidepressants do not exert any positive effects. Although the above positive effects manifest all the antidepressants do have specific side-effects that may impair your daily life. For example a feeling of tiredness is a common side-effect in the beginning of the antidepressant therapy which passes within a few weeks. It is important to take the medicine even after you start feeling better. A consultation with you health care provider is necessary before stopping the treatment as for many antidepressants the treatment should be stopped gradually.

Different group of antidepressants currently exist among them are:

  • MAO inhibitors - monoamine oxidase inhibitors
    • Selective MAO inhibitors
    • Non-selective MAO inhibitors
  • Preparations that block neuronal reuptake of amines
    • Non-selective blockers of norepinephrine and serotonin reuptake
    • Selective serotonin reuptake inhibitors
    • Selective norepinephrine reuptake inhibitors
  • Monoamine receptors agonists